6,6-Fused heterocyclic ureas as highly potent TRPV1 antagonists was written by Sun, Wei;Kim, Hyo-Shin;Lee, Sunho;Jung, Aeran;Kim, Sung-Eun;Ann, Jihyae;Yoon, Suyoung;Sun, Choi;Lee, Jin Hee;Blumberg, Peter M.;Frank-Foltyn, Robert;Bahrenberg, Gregor;Schiene, Klaus;Stockhausen, Hannelore;Christoph, Thomas;Frormann, Sven;Lee, Jeewoo. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2015.Related Products of 23707-37-1 This article mentions the following:
A series of N-[{2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)-pyridin-3-yl}methyl] N’-(6,6-fused heterocyclic) ureas have been investigated as hTRPV1 antagonists. Among them, compound (I) showed highly potent TRPV1 antagonism to capsaicin, with Ki(ant) = 0.2 nM, as well as antagonism to other activators, and it was efficacious in a pain model. A docking study of I with our hTRPV1 homol. model indicates that there is crucial hydrogen bonding between the ring nitrogen and the receptor, contributing to its potency. In the experiment, the researchers used many compounds, for example, Isoquinolin-7-amine (cas: 23707-37-1Related Products of 23707-37-1).
Isoquinolin-7-amine (cas: 23707-37-1) belongs to isoquinoline derivatives. The isoquinoline structure occurs in a considerable number of alkaloids in widely separated plant families. The Pomeranz–Fritsch reaction provides a method for the preparation of isoquinoline. This reaction uses a benzaldehyde and aminoacetoaldehyde diethyl acetal, which in an acid medium react to form isoquinoline.Related Products of 23707-37-1
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem