Jayne, Charles L. et al. published their research in Bioorganic & Medicinal Chemistry Letters in 2020 | CAS: 23707-37-1

Isoquinolin-7-amine (cas: 23707-37-1) belongs to isoquinoline derivatives. Quinoline is a mancude organic heterobicyclic parent, an azaarene, an ortho-fused heteroarene and a member of isoquinolines. Most traditional methods of generating isoquinoline do so via oxidative aromatization of dihydro- or tetrahydro-isoquinolines, usually offering some environmental or economic advantage.Category: isoquinoline

Discovery of hydroxy pyrimidine Factor IXa inhibitors was written by Jayne, Charles L.;Andreani, Teresa;Chan, Tin-Yau;Chelliah, Mariappan V.;Clasby, Martin C.;Dwyer, Michael;Eagen, Keith A.;Fried, Steve;Greenlee, William J.;Guo, Zhuyan;Hawes, Brian;Hruza, Alan;Ingram, Richard;Keertikar, Kartik M.;Neelamkavil, Santhosh;Reichert, Paul;Xia, Yan;Chackalamannil, Samuel. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2020.Category: isoquinoline This article mentions the following:

The synthesis and structure activity relationship development of a pyrimidine series of heterocyclic Factor IXa inhibitors, I and II [R = Q, Q1, Q2, etc.], is described. Increased selectivity over Factor Xa inhibition was achieved through SAR expansion of the P1 element. Select compounds were evaluated in vivo to assess their plasma levels in rat. In the experiment, the researchers used many compounds, for example, Isoquinolin-7-amine (cas: 23707-37-1Category: isoquinoline).

Isoquinolin-7-amine (cas: 23707-37-1) belongs to isoquinoline derivatives. Quinoline is a mancude organic heterobicyclic parent, an azaarene, an ortho-fused heteroarene and a member of isoquinolines. Most traditional methods of generating isoquinoline do so via oxidative aromatization of dihydro- or tetrahydro-isoquinolines, usually offering some environmental or economic advantage.Category: isoquinoline

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem