Neelakantan, Harshini et al. published their research in Journal of Medicinal Chemistry in 2017 | CAS: 23707-37-1

Isoquinolin-7-amine (cas: 23707-37-1) belongs to isoquinoline derivatives. Quinoline is a catabolite of tryptophan, the basic structure of some antihypertensive drugs, such as the peripheral vasodilators prazosin and doxazosin. The discovery of chloroquine, the most well-known drug containing this stent, has helped bring about decades of malaria control and treatment.Safety of Isoquinolin-7-amine

Structure-Activity Relationship for Small Molecule Inhibitors of Nicotinamide N-Methyltransferase was written by Neelakantan, Harshini;Wang, Hua-Yu;Vance, Virginia;Hommel, Jonathan D.;McHardy, Stanton F.;Watowich, Stanley J.. And the article was included in Journal of Medicinal Chemistry in 2017.Safety of Isoquinolin-7-amine This article mentions the following:

Nicotinamide N-methyltransferase (NNMT) is a fundamental cytosolic biotransforming enzyme that catalyzes the N-methylation of endogenous and exogenous xenobiotics. We have identified small mol. inhibitors of NNMT with >1000-fold range of activity and developed comprehensive structure-activity relationships (SARs) for NNMT inhibitors. Screening of N-methylated quinolinium, isoquinolinium, pyrididium, and benzimidazolium/benzothiazolium analogs resulted in the identification of quinoliniums as a promising scaffold with very low micromolar (IC50 âˆ?1 μM) NNMT inhibition. Computer-based docking of inhibitors to the NNMT substrate (nicotinamide)-binding site produced a robust correlation between ligand-enzyme interaction docking scores and exptl. calculated IC50 values. Predicted binding orientation of the quinolinium analogs revealed selective binding to the NNMT substrate-binding site residues and essential chem. features driving protein-ligand intermol. interactions and NNMT inhibition. The development of this new series of small mol. NNMT inhibitors direct the future design of lead drug-like inhibitors to treat several metabolic and chronic disease conditions characterized by abnormal NNMT activity. In the experiment, the researchers used many compounds, for example, Isoquinolin-7-amine (cas: 23707-37-1Safety of Isoquinolin-7-amine).

Isoquinolin-7-amine (cas: 23707-37-1) belongs to isoquinoline derivatives. Quinoline is a catabolite of tryptophan, the basic structure of some antihypertensive drugs, such as the peripheral vasodilators prazosin and doxazosin. The discovery of chloroquine, the most well-known drug containing this stent, has helped bring about decades of malaria control and treatment.Safety of Isoquinolin-7-amine

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem