Practical and Asymmetric Reductive Coupling of Isoquinolines Templated by Chiral Diborons was written by Chen, Dongping;Xu, Guangqing;Zhou, Qinghai;Chung, Lung Wa;Tang, Wenjun. And the article was included in Journal of the American Chemical Society in 2017.Reference of 36034-54-5 This article mentions the following:
We herein describe a chiral diboron-templated highly diastereoselective and enantioselective reductive coupling of isoquinolines that provided expedited access to a series of chiral substituted bisisoquinolines, e. g., I, in good yields and excellent ee’s under mild conditions. The method enjoys a broad substrate scope and good functional group compatibility. Mechanistic investigation suggests the reaction proceeds through a concerted [3,3]-sigmatropic rearrangement. In the experiment, the researchers used many compounds, for example, 4-Methoxyisoquinoline (cas: 36034-54-5Reference of 36034-54-5).
4-Methoxyisoquinoline (cas: 36034-54-5) belongs to isoquinoline derivatives. Quinoline and isoquinoline skeletons are among the most attractive frameworks with a wide range of biological and pharmacological activities. They are also used to make oil-soluble dyes, food colorants, pharmaceuticals, pH indicators and other organic compounds. Reference of 36034-54-5
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem