Antiblastic properties of berberine and its derivatives was written by Shvarev, I. F.;Tsetlin, A. L.. And the article was included in Farmakologiya i Toksikologiya (Moscow) in 1972.Computed Properties of C40H36N2O12S This article mentions the following:
Berberine sulfate (I) [316-41-6] at 50 μg/ml or berberine chloride [633-65-8] at 25 μg/ml were cytostatic toward Ehrlich and lymphoma ascitic tumor cells suspended in medium. Me berberolineacetate at 500 μg/ml did not affect the growth of the cells. Berberine [2086-83-1] (2.5-7.5 mg/kg/day i.p.) or 9-berberoline [17388-19-1] (5-40 mg/kg/day i.p.) did not prevent the development of ascitic tumor in mice and did not prolong the life span of the animals. In the experiment, the researchers used many compounds, for example, 9,10-Dimethoxy-5,6-dihydro-[1,3]dioxolo[4,5-g]isoquinolino[3,2-a]isoquinolin-7-ium sulfate(2:1) (cas: 316-41-6Computed Properties of C40H36N2O12S).
9,10-Dimethoxy-5,6-dihydro-[1,3]dioxolo[4,5-g]isoquinolino[3,2-a]isoquinolin-7-ium sulfate(2:1) (cas: 316-41-6) belongs to isoquinoline derivatives. Isoquinoline is a structural isomer of quinoline, which have antiseptic, antipyretic and anti-cyclic properties, and can be used as antimalarial drugs and for the preparation of other antimalarial medicine. The discovery of chloroquine, the most well-known drug containing this stent, has helped bring about decades of malaria control and treatment.Computed Properties of C40H36N2O12S
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem