Rapid Synthesis of Aryl Fluorides in Continuous Flow through the Balz-Schiemann Reaction was written by Park, Nathaniel H.;Senter, Timothy J.;Buchwald, Stephen L.. And the article was included in Angewandte Chemie, International Edition in 2016.Synthetic Route of C9H6FN This article mentions the following:
The Balz-Schiemann reaction remains a highly used means for preparing aryl fluorides from anilines. However, the limitations associated with handling aryl diazonium salts often hinder both the substrate scope and scalability of this reaction. To address this, a new continuous flow protocol was developed that eliminates the need to isolate the aryl diazonium salts. The new process has enabled the fluorination of an array of aryl and heteroaryl amines. In the experiment, the researchers used many compounds, for example, 4-Fluoroisoquinoline (cas: 394-67-2Synthetic Route of C9H6FN).
4-Fluoroisoquinoline (cas: 394-67-2) belongs to isoquinoline derivatives. Quinoline and its derivatives are widely used as fungicides, biological agents, antibiotics, alkaloids, dyes, rubber chemicals and flavoring agents. They are also used to make oil-soluble dyes, food colorants, pharmaceuticals, pH indicators and other organic compounds. Synthetic Route of C9H6FN
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem