Regioselective peri-C-H selenylation of aromatic compounds with weakly coordinating ketone groups was written by Duan, Bingbing;Wu, Yao;Gao, Yi;Ying, Linkun;Tang, Jielin;Hu, Shiyu;Zhao, Qiuhua;Song, Zengqiang. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2022.Safety of 1-Hydroxyisoquinoline This article mentions the following:
A novel and versatile method for peri-C-H selenylation of aromatic compounds bearing ketone groups, including chromones, xanthones, acridinones, quinolinones and naphthoquinones with diselenides under Ru(II) catalysis was presented. Various chromones and diselenides were applicable for this transformation, affording 5-selenyl chromones I [R1 = H, 8-Cl, 2-Ph, etc.; R2 = Ph, 3-FC6H4, 4-ClC6H4, etc.] in a highly regioselective manner in good to excellent yields. This transformation was easy to scale up and the desired products can be further modified. Most importantly, this transformation allowed the late-stage selenylation of bioactive compounds Mechanistic studies showed that radicals may be involved in this novel transformation. In the experiment, the researchers used many compounds, for example, 1-Hydroxyisoquinoline (cas: 491-30-5Safety of 1-Hydroxyisoquinoline).
1-Hydroxyisoquinoline (cas: 491-30-5) belongs to isoquinoline derivatives. Quinoline and isoquinoline skeletons are among the most attractive frameworks with a wide range of biological and pharmacological activities. Isoquinoline-type alkaloids show biological activities similar to those of morphinane-, protoberberine-, and benzophenanthridine-type alkaloids.Safety of 1-Hydroxyisoquinoline
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem