Determination of related substances in fasudil hydrochloride by HPLC was written by Ge, Xin;Meng, Xiangjun;Li, Naran. And the article was included in Guangpu Shiyanshi in 2011.Computed Properties of C14H18ClN3O2S This article mentions the following:
The determination of related substances in fasudil hydrochloride was investigated by HPLC on C18 column, with methanol-ammonium dihydrogen phosphate (30:70, adjusting pH to 3.5 卤 0.05 with phosphoric acid) as mobile phase at the detection wavelength of 275 nm. The detection limit was 0.3 mg/mL for fasudil hydrochloride, and the main compound peak could entirely sep. from related substances. The method is simple, accurate and sensitive, that can be applied for determination of related substances in fasudil hydrochloride. In the experiment, the researchers used many compounds, for example, 5-((1,4-Diazepan-1-yl)sulfonyl)isoquinoline hydrochloride (cas: 105628-07-7Computed Properties of C14H18ClN3O2S).
5-((1,4-Diazepan-1-yl)sulfonyl)isoquinoline hydrochloride (cas: 105628-07-7) belongs to isoquinoline derivatives. Quinoline and isoquinoline skeletons are among the most attractive frameworks with a wide range of biological and pharmacological activities. Lewis acid activation and nucleophilic attack can produce multiple regioisomers in quinolines and pyridines; isoquinolines generally only undergo attack at the 1-position.Computed Properties of C14H18ClN3O2S
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem