UPLC-MS coupled with a dynamic multiple data processing method for the comprehensive detection of the chemical constituents of the herbal formula San-Miao-Wan was written by Zou, Di;Zhang, Ai-hua;Yan, Guang-li;Tan, Yun-long;Sun, Hui;Wang, Xi-jun. And the article was included in Analytical Methods in 2014.Product Details of 3382-18-1 This article mentions the following:
San-Miao-Wan (SMW) is a combination prescription of Cortex Phellodendri Chinensis, Rhizoma Atractylodis, and Radix Achyranthis Bidentatae commonly used to treat arthritis and hyperuricemia, described in the State Pharmacopoeia of the People’s Republic of China. However, despite numerous pharmacol. studies, the phytochem. constituents of SMW were not conclusively identified. In the present study, a universally applicable UPLC-ESI-Q-TOF-MS technique coupled with a multiple data processing approach (Mdpa) was developed to carry out comprehensive detection of the chem. constituents of SMW. The Mdpa method can efficiently deal with the large volumes of mass data collected via the use of spectral and chromatog. search algorithms that detect ions at low concentrations Using an UPLC system, the total anal. time for separation was < 20 min without the loss of any resolution In the principal component anal. VIP-plot, 77 ions of interest (36 ions in pos. mode, 43 ions in neg. mode, and 2 ions in both modes) were extracted Based on the MS fragmentation patterns of the reference standards, a total of 71 components were identified or tentatively characterized by comparing their retention times, UV and MS spectra with those of reference standards, or through the matching of empirical information with those of the published components in the inhouse library. Our results indicated that the developed method could be used as a rapid and effective technique for the structural characterization of phytochem. constituents in SMW. This work is also expected to provide comprehensive information for the quality evaluation study of SMW. In the experiment, the researchers used many compounds, for example, 6,7-Dimethoxy-3,4-dihydroisoquinoline (cas: 3382-18-1Product Details of 3382-18-1).
6,7-Dimethoxy-3,4-dihydroisoquinoline (cas: 3382-18-1) belongs to isoquinoline derivatives. Although isoquinoline derivatives can be synthesized by several methods, relatively few direct methods deliver the unsubstituted isoquinoline. The discovery of chloroquine, the most well-known drug containing this stent, has helped bring about decades of malaria control and treatment.Product Details of 3382-18-1
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem