486-73-7, Isoquinoline-1-carboxylic acid is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
General procedure: To a solution of carboxylic acid (1.0 mmol) in anhydrous THF (20 mL) were added (2S,3R)-2-amino-3-hydroxy-N-alkylbutanamide 4a-d (1.0 mmol) and HOBt (1.0 mmol, 0.135 g) at 0 C. After the reaction mixture was stirred for 5 min, EDC¡¤HCl (0.220 g, 1.1 mmol) was added. The pH value of the solution was adjusted to 8-9 with 4-methylmorpholine. The reaction mixture was stirred at 0 C for 2 h and overnight at room temperature. After evaporation of the mixture in vacuo, the residue was dissolved in ethyl acetate (50 mL). The solution was washed successively with saturated NaHCO3, 5% KHSO4, and saturated NaCl. The organic phase was separated and dried over anhydrous MgSO4. After filtration and evaporation in vacuo, residue was purified by recrystallization in petroleum ester/ethyl acetate to give the desired ceramide analogues 5xa-xj.
486-73-7 Isoquinoline-1-carboxylic acid 68092, aisoquinoline compound, is more and more widely used in various.
Reference£º
Article; Liu, Qianqian; Li, Xia; Bao, Yong-Sheng; Lu, Jingxin; Li, Hua; Huang, Zhizhen; Liu, Feiyan; Bioorganic and Medicinal Chemistry; vol. 27; 8; (2019); p. 1489 – 1496;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem