With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.891785-28-7,6-Bromoisoquinolin-3-amine,as a common compound, the synthetic route is as follows.
891785-28-7, Step 1 To a solution of 6-bromoisoquinolin-3-amine (XX)(3.0 g, 13.45 mmol)and 2-((1-(tert-butoxycarbonyl)piperidin-4-yl)oxy)isonicotinic acid (XII)(10.62 g, 32.94 mmol)in DCE was added DMAP (1.64 g, 13.45 mmol), DIPEA (7.03 mL, 40.35 mmol), HATU (12.32 g, 32.4 mmol)to DCE (67.2 mL)stirred at 75 C. for 16 hours. The solvent was removed under vacuum and putified by silica gel (40 g)using 0 to 50% EtOAc/hexanes to produce tert-butyl 4-((4-((6-bromoisoquinolin-3-yl)carbamoyl)pyridin-2-yl)oxy)piperidine-1-carboxylate (XLIV)as an off-white solid (4.37 g, 8.29 mmol, 61.6% yield). ESIMS found for C25H27BrN4O4 m/z 426.1 (M-Boc).
As the paragraph descriping shows that 891785-28-7 is playing an increasingly important role.
Reference£º
Patent; Samumed, LLC; KC, Sunil Kumar; Mak, Chi Ching; Eastman, Brian Walter; Cao, Jianguo; Bollu, Venkataiah; Mittapalli, Gopi Kumar; Chiruta, Chandramouli; (218 pag.)US2017/313682; (2017); A1;,
Isoquinoline – Wikipedia
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