23687-26-5, 6-Aminoisoquinoline is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
K3P04 (0.449 g, 2.117 mmol), Pd2(dba)3 (0.040 g 0.0441 mmol) and Xantphos (0.043 g, 0.0735 mmol) were added to a solution of intermediate 16 (0.153 g, 0.809 mmol) in THF (4 mL) while nitrogen was bubbling through the mixture. After 10 min, isoquinolin-6-amine (0.106 g, 0.735 mmol) was added and the mixture was stirred at rt for 10 min. Then, the mixture was heated at 100 ¡ãC for 16 h. The mixture was washed with aq. sat. NaHC03 and extracted with EtOAc. The combined org layers were dried over MgSC , filtered and the solvent was evaporated in vacuo. The crude product was purified by flash column chromatography; (silica; EtOAc in Heptane, 0/100 to 35/65). The desired fractions were collected and concentrated in vacuo. The residue was dissolved in DCM, HC1 (5 N in 2-propanol) was added and the mixture was concentrated in vacuo. The residue was triturated with DIPE and filtered to yield compound 10 as a yellow solid (0.147 g, 47percent). ‘H NMR (300 MHz, DMSO-d6) delta ppm 2.00 – 2.23 (m, 2 H) 4.16 (t, J=6.2 Hz, 2 H) 4.63 (dt, J=47.3, 5.8 Hz, 2 H) 7.18 (d, J=8.9 Hz, 1 H) 7.51 (dd, J=8.9, 3.0 Hz, 1 H) 7.91 (dd, J=9.2, 1.4 Hz, 1 H) 8.07 (d, J=6.7 Hz, 1 H) 8.13 (d, J=2.7 Hz, 1 H) 8.28 (d, J=9.1 Hz, 1 H) 8.34 (d, J=6.6 Hz, 1 H) 8.63 (s, 1 H) 9.41 (s, 1 H) 10.44 (s, 1 H), 23687-26-5
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Reference£º
Patent; JANSSEN PHARMACEUTICA NV; ANDRES-GIL, Jose, Ignacio; BORMANS, Guy, Maurits, R.; DECLERCQ, Lieven, Denis, Herwig; FIERENS, Katleen; LEENAERTS, Joseph, Elisabeth; MOECHARS, Diederik, Willem, Elisabeth; ROMBOUTS, Frederik, Jan, Rita; KOLB, Hartmuth; ZHANG, Wei; (67 pag.)WO2018/15307; (2018); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem