34784-05-9, 6-Bromoisoquinoline is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a suspension of 6-bromoisoquinoline (624 mg, 3.0 mmol) and Pd(PPh3)4 (173 mg, 0.15 mmol) in DMF (6 mL) was added Zn(CN)2 (210 mg, 1.8 mmol), and the reaction mixture was stirred at 90 C under N2 for 24 h. After cooling to room temperature, H2O (40 mL) was added and the mixture was extracted with ethyl acetate (40 mL x 3). The combined organic layers were washed with brine (30 mL x 3) and dried over Na2SO4. After concentration and purification by column chromatography (petroleum ether/ethylacetate = 3:1), 55 was obtained as a white solid (360 mg, 78%). 1H NMR (400 MHz, CDCl3) d 9.37 (s, 1H), 8.70 (d, J = 5.6 Hz, 1H),8.25 (s, 1H), 8.10 (d, J = 8.4 Hz, 1H), 7.77 (d, J = 8.4 Hz, 1H), 7.73(d, J = 5.6 Hz, 1H)., 34784-05-9
The synthetic route of 34784-05-9 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Xu, Zhixiang; Xu, Xiangxiang; O’Laoi, Ruadhan; Ma, Haikuo; Zheng, Jiyue; Chen, Shuaishuai; Luo, Lusong; Hu, Zhilin; He, Sudan; Li, Jiajun; Zhang, Hongjian; Zhang, Xiaohu; Bioorganic and Medicinal Chemistry; vol. 24; 22; (2016); p. 5861 – 5872;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem