With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1532-97-4,4-Bromoisoquinoline,as a common compound, the synthetic route is as follows.
Step A: Ethylene glycol dimethyl ether (20 mL) and 2 N Na2CO3 (12.2 mL) were sparged with N2 and charged to a round bottom flask containing 4-bromoisoquinoline (2 g, 9.6 mmol), phenylboronic acid (1.76 g, 14.4 mmol), and Pd(PPh3)4 (1.11 g, 0.96 mmol). The entire solution was sparged with N2. The resulting reaction mixture was heated to reflux under N2 overnight. The solution was cooled, quenched with saturated NaHCO3 (230 mL), and extracted five times with ethyl ether. The combined organic was dried over Na2SO4, filtered, and the solvent was removed in vacuo to yield an orange oil. Column chromatography (1:1 ethyl acetate/hexanes) afforded the pure isoquinoline as a yellow oil which crystallized upon refrigeration (2.21 g). 1H NMR (300 MHz, CDCl3) delta 9.29 (s, 1H), 8.52 (s, 1H), 8.04 (d, 1H, J=8.4 Hz), 7.91 (d, 1H, J=8.1 Hz), 7.66 (m, 2H), 7.46 (m, 5H).
1532-97-4, The synthetic route of 1532-97-4 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Molino, Bruce F.; Berkowitz, Barry; Cohen, Marlene; US2006/111393; (2006); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem