Analyzing the synthesis route of 1350643-72-9

The synthetic route of 1350643-72-9 has been constantly updated, and we look forward to future research findings.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1350643-72-9,(S)-3-(1-Aminoethyl)-8-chloro-2-phenylisoquinolin-1(2H)-one,as a common compound, the synthetic route is as follows.

A mixture of (S)-3-(l-aminoethyl)-8-chloro-2-phenylisoc]uinolm-l(2H)-one (202 mg, 0.676 fflffiol), 6-chloro-5-iodo-pyrimidm-4-arnine (257mg, 1.0 mmol) and triethylamine (340 mg, 3.36 mmol) in n-BuOH (2.0 ml) was heated to reflux and stirred further for 47 hours, then cooled to it, and concentrated in vacuo. The residue was purified by a silica gel column chromatography (DCM/MeOH (v/v) = 100/1) to give the title compound as a yellowish solid (145 mg, yield 41%). MS (ESI, pos. ion) m/z: 517.6 [M+H]+., 1350643-72-9

The synthetic route of 1350643-72-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; CALITOR SCIENCES, LLC; SUNSHINE LAKE PHARMA CO., LTD.; XI, Ning; WANG, Liang; WANG, Tingjin; WU, Weibin; (123 pag.)WO2015/175579; (2015); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem