13130-79-5, 1-Bromoisoquinolin-3-amine is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a solution of 1-bromoisoquinolin-3-amine (200 mg, 0.897 mmol, Maybridge Chemical Co., Altrincham, UK) in tetrahydrofuran (5 mL) at rt was added sodium bis(trimethylsilyl)amide (1M solution in tetrahydrofuran, 1.79 mL, 1.79 mmol). The mixture was stirred for 10 mm before a solution of Boc-anhydnde (0.208 mL, 0.897 mmol) in THF (1 mL) was added. The reaction mixture was stirred for 5 mm before being diluted with sat. aq. NH4C1 (50 mL) and EtOAc (50 mL). The organic layer was separated, dried over Na2SO4, filtered, and concentrated. Purification by silica gel column chromatography eluting with 0-20% EtOAc in heptane afforded tert-butyl (1-bromoisoquinolin-3-yl)carbamate. m/z (ESI, +ve) 345.0 (M+Na)t
13130-79-5, 13130-79-5 1-Bromoisoquinolin-3-amine 289845, aisoquinoline compound, is more and more widely used in various fields.
Reference£º
Patent; AMGEN INC.; LANMAN, Brian Alan; CEE, Victor J.; PICKRELL, Alexander J.; REED, Anthony B.; YANG, Kevin C.; KOPECKY, David John; WANG, Hui-Ling; LOPEZ, Patricia; ASHTON, Kate; BOOKER, Shon; TEGLEY, Christopher M.; (303 pag.)WO2018/119183; (2018); A2;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem