Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments. 4721-98-6. Introducing a new discovery about 4721-98-6, Name is 6,7-Dimethoxy-1-methyl-3,4-dihydroisoquinoline
THE SYNTHESIS OF THE ISOQUINOLINE ALKALOID CALYCOTOMINE VIA FUNCTIONALIZATION OF ENAMIDE DOUBLE BONDS
The novel alkaloid calycotomine, a 1-hydroxymethylenetetrahydroisoquinoline, has been synthesized from 1-methyl-3,4-dihydroisoquinoline via the 2-benzyloxycarbonyl enamide derivative.Oxidation of the enamide with osmium tetroxide results in bis-hydroxylation and ring opening to form hydroxyacetophenone carbamates.Hydrogenation results in reclosure of the isoquinoline ring and further reduction yielding 1-hydroxymethylenetetrahydroisoquinolines.
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Reference£º
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem