Synthetic Route of 22246-12-4, Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Patent, and a compound is mentioned, 22246-12-4, 6-Methoxy-3,4-dihydroisoquinolin-1(2H)-one, introducing its new discovery.
The compounds of the formula STR1 wherein R represents hydrogen, lower alkyl, aryl, biaryl, C3 -C7 -cycloalkyl, aryl-lower alkyl, aryl-lower alkenyl, aryl-lower alkynyl, aryloxy-lower alkyl, arylthio-lower alkyl, C3 -C7 -cycloalkyl-lower alkyl, biaryl-lower alkyl, aryl-C3 -C7 -cycloalkyl, aryl-C3 -C7 -cycloalkyl-lower alkyl or aryloxy-aryl-lower alkyl; and aryl represents carbocyclic or heterocyclic aryl; Z represents C1 -C3 -alkylene or vinylene, each unsubstituted or substituted by lower alkyl; Y represents SO2 (sulfonyl) or CO (carbonyl); A represents 0 (oxygen), S (sulfur), or a direct bond; B represents lower alkylene; or B represents lower alkenylene or lower alkynylene provided that A represents a direct bond; X represents oxygen or sulfur, R1 represents hydrogen, acyl, lower alkoxycarbonyl, aminocarbonyl, mono- or di-lower alkylaminocarbonyl, lower alkenylaminocarbonyl, lower alkynylaminocarbonyl, carbocyclic or heterocyclic aryl-lower alkylaminocarbonyl, carbocyclic or heterocyclic arylaminocarbonyl, C3 -C7 -cycloalkylaminocarbonyl or C3 -C7 -cycloalkyl-lower alkylaminocarbonyl; R2 represents lower alkyl, lower alkoxycarbonyl-lower alkyl, C3 -C7 -cycloalkyl, carbocyclic or heterocyclic aryl, carbocyclic or heterocyclic aryl-lower alkyl, C3 -C7 -cycloaikyl-lower alkyl, amino, mono- or di-lower alkylamino, lower alkenylamino, lower alkynylamino, carbocyclic or heterocyclic aryl-lower alkylamino, carbocyclic or heterocyclic arylamino, C3 -C7 -cycloalkylamino, C3 -C7 -cycloalkyl-lower alkylamino or lower alkoxycarbonyl-lower alkylamino; R3 and R4 independently represent hydrogen or lower alkyl; Ra represents hydrogen, lower alkyl, halo, trifluoromethyl or lower alkoxy; and pharmaceutically acceptable salts thereof; and their preparation and use as lipoxygenase inhibitors are described.
Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Synthetic Route of 22246-12-4. In my other articles, you can also check out more blogs about 22246-12-4
Reference：
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem