4602-73-7, Name is 7-Hydroxy-6-methoxy-3,4-dihydroisoquinoline, belongs to isoquinoline compound, is a common compound. Formula: C10H11NO2In an article, once mentioned the new application about 4602-73-7.
Indole and phthalide are privileged heterocyclic scaffolds in numerous natural products and bioactive molecules. The synthesis and biological evaluation of the compounds combining these two scaffolds have rarely been reported. Herein, we repot the first palladium-catalyzed ligand-free double cyclization reactions that enable efficient synthesis of 3-(1?-indolyl)-phthalides (42 examples, up to 96% yield) under mild conditions. Notably, only 1.0 mol % of catalyst loading is used, suggesting high efficiency. Late-stage elaborations give highly functionalized analogues.
Do you like my blog? If you like, you can also browse other articles about this kind. Thanks for taking the time to read the blog about 4602-73-7
Reference：
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem