4721-98-6, Name is 6,7-Dimethoxy-1-methyl-3,4-dihydroisoquinoline, belongs to isoquinoline compound, is a common compound. Recommanded Product: 6,7-Dimethoxy-1-methyl-3,4-dihydroisoquinolineIn an article, once mentioned the new application about 4721-98-6.
The reaction of the anion of 3-methoxyphthalide with 3,4-dihydroisoquinolines affords 13-spiro-substituted protoberberines rather than the expected 8,13-dioxo derivatives. Whilst the parent 3,4-dihydroisoquinoline reacts stereospecifically to yield the (13S*,13aS*) diastereomer, the 1-methyl derivative affords exclusively the (13R*,13aS*) isomer. This change in stereochemical outcome is attributed to conformational changes induced by the methyl group in the putative 8,13-dioxo-intermediates.
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Reference：
Isoquinoline – Wikipedia,
Isoquinoline | C9H2777N – PubChem