SDS of cas: 156478-71-6. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 2-(4-(tert-Butoxycarbonyl)piperazin-1-yl)acetic acid, is researched, Molecular C11H20N2O4, CAS is 156478-71-6, about Potent Body Weight-Lowering Effect of a Neuromedin U Receptor 2-selective PEGylated Peptide.
Neuromedin U (NMU) is a neuropeptide that mediates a variety of physiol. functions via its receptors, NMUR1 and NMUR2. Recently, there has been an increased focus on NMU as a promising treatment option for diabetes and obesity. A short form of NMU (NMU-8) has potent agonist activity for both receptors but is metabolically unstable. Therefore, we designed and synthesized NMU-8 analogs modified by polyethylene glycol (PEG; mol. weight, 20 kDa; PEG20k) via a linker. 3-(2-Naphthyl)alanine substitution at position 19 increased NMUR2 selectivity of NMU-8 analogs with retention of high agonist activity. Compound 37, an NMUR2-selective PEG20k analog containing piperazin-1-ylacetyl linker, exhibited a potent body weight-lowering effect with concomitant inhibition of food intake in a dose-dependent manner (body weight loss of 12.4% at 30 nmol/kg) by once-daily repeated dosing for 2 wk in mice with diet-induced obesity.
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Reference:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem