Safety of 5-Bromo-3-methoxypyridin-2-amine. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 5-Bromo-3-methoxypyridin-2-amine, is researched, Molecular C6H7BrN2O, CAS is 42409-58-5, about Directing Group Enables Electrochemical Selectively Meta-Bromination of Pyridines under Mild Conditions.
Without the use of catalysts and oxidants, a facile and sustainable electrochem. bromination protocol was developed. By introducing the directing groups, the regioselectivity of pyridine derivatives could be controlled at the meta-position utilizing the inexpensive and safe bromine salts at room temperature A variety of brominated pyridine derivatives were obtained in 28-95% yields, and the reaction could be readily performed at a gram scale. By combining the installation and removing the directing group, the concept of meta-bromination of pyridines could be verified.
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Reference:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem