Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 42409-58-5, is researched, SMILESS is BrC1=CN=C(C(=C1)OC)N, Molecular C6H7BrN2OJournal, Article, Bioconjugate Chemistry called DNA-Compatible Copper-Catalyzed Oxidative Amidation of Aldehydes with Non-Nucleophilic Arylamines, Author is Li, Ke; Qu, Yi; An, Yulong; Breinlinger, Eric; Webster, Matthew P.; Wen, Huanan; Ding, Duanchen; Zhao, Meng; Shi, Xiaodong; Wang, Jiangong; Su, Wenji; Cui, Weiren; Satz, Alexander L.; Yang, Hongfang; Kuai, Letian; Little, Andrew; Peng, Xuanjia, the main research direction is amide preparation DNA encoded library oxidative amidation; copper catalyzed on DNA oxidative amidation aldehyde arylamine.Safety of 5-Bromo-3-methoxypyridin-2-amine.
We report a DNA-compatible protocol for synthesizing amides from DNA-bound aldehydes and non-nucleophilic arylamines including aza-substituted anilines, 2-aminobenzimidazoles, and 3-aminopyrazoles. The reactions were carried out at room temperature and provided reasonable conversions and wide functional group compatibility. The reactions were also successful when employing aryl and aliphatic aldehydes. In addition, qPCR and NGS data suggested no neg. impact on DNA integrity after the copper-mediated oxidative amidation reaction.
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Reference:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem