The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 1,5-Diphenyl-1H-pyrazole-3-carboxylic acid(SMILESS: OC(=O)C1=NN(C(=C1)C1=CC=CC=C1)C1=CC=CC=C1,cas:13599-22-9) is researched.Safety of 3,5-Di(pyridin-2-yl)-4H-1,2,4-triazol-4-amine. The article 《Discovery of 1,5-Diphenylpyrazole-3-Carboxamide Derivatives as Potent, Reversible, and Selective Monoacylglycerol Lipase (MAGL) Inhibitors》 in relation to this compound, is published in Journal of Medicinal Chemistry. Let’s take a look at the latest research on this compound (cas:13599-22-9).
Monoacylglycerol lipase (MAGL) is a serine hydrolase that plays an important role in the degradation of the endocannabinoid neurotransmitter 2-arachidonoylglycerol, which is implicated in many physiol. processes. Beyond the possible utilization of MAGL inhibitors as anti-inflammatory, antinociceptive, and anticancer agents, their application has encountered obstacles due to the unwanted effects caused by the irreversible inhibition of this enzyme. The possible application of reversible MAGL inhibitors has only recently been explored, mainly due to the deficiency of known compounds possessing efficient reversible inhibitory activities. The authors report a new series of reversible MAGL inhibitors. Among them, compound 26 ((4-benzylpiperidin-1-yl)(5-(4-hydroxyphenyl)-1-(3-methylbenzyl)-1H-pyrazol-3-yl)methanone) showed to be a potent MAGL inhibitor (IC50 = 0.51 μM, Ki = 412 nM) with a good selectivity vs. fatty acid amide hydrolase (FAAH), α/β-hydrolase domain-containing 6 (ABHD6), and 12 (ABHD12). Interestingly, this compound also possesses antiproliferative activities against two different cancer cell lines and relieves the neuropathic hypersensitivity induced in vivo by oxaliplatin.
In some applications, this compound(13599-22-9)Safety of 1,5-Diphenyl-1H-pyrazole-3-carboxylic acid is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.
Reference:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem