Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 1671-88-1, is researched, Molecular C12H10N6, about Synthesis, characterization, DNA/protein interaction and cytotoxicity studies of Cu(II) and Co(II) complexes derived from dipyridyl triazole ligands, the main research direction is cobalt copper dipyridyltriazole complex preparation structure anticancer DNA binding; crystal structure cobalt copper dipyridyltriazole complex; BSA; Cytotoxic activity; DNA; Dipyridyl triazole ligands.Application In Synthesis of 3,5-Di(pyridin-2-yl)-4H-1,2,4-triazol-4-amine.
Four different transition metal complexes containing dipyridyltriazole ligands, [Cu(abpt)2Cl2]·2H2O (1; abpt = 4-amino-3,5-bis(pyridin-2-yl)-1,2,4-triazole), [Cu(abpt)2(ClO4)2] (2), [Co2(abpt)2(H2O)2Cl2]Cl2·4H2O (3) and [Co2(bpt)2(CH3OH)2(NO3)2] (4; Hbpt = 3,5-bis(pyridin-2-yl)-1,2,4-triazole) were designed, synthesized and further structurally characterized by x-ray crystallog., ESI-MS, elemental anal., IR and Raman spectroscopy. In these complexes, the both ligands act as bidentate ligands with N, N donors. DNA binding interactions with calf thymus DNA (ct-DNA) of the ligand and its complexes 1-4 were investigated via electronic absorption, fluorescence quenching, CD and viscosity measurements as well as confocal Laser Raman spectroscopy. The results show these complexes are able to bind to DNA via the noncovalent mode i.e. intercalation and groove binding or electrostatic interactions. The interactions with bovine serum albumin (BSA) were also studied using UV-visible and fluorescence spectroscopic methods which indicated that fluorescence quenching of BSA by these compounds was the presence of both static and dynamic quenching. Also, the in vitro cytotoxic effects of the complexes against four cell lines SK-OV-3, HL-7702, BEL7404 and NCI-H460 showed the necessity of the coordination action on the biol. properties on the resp. complex and that all four complexes exhibited substantial cytotoxic activity.
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Reference:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem