Application In Synthesis of (3aR,8aR)-2,2-Dimethyl-4,4,6,8,8-pentaphenyltetrahydro-[1,3]dioxolo[4,5-e][1,3,2]dioxaphosphepine. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: (3aR,8aR)-2,2-Dimethyl-4,4,6,8,8-pentaphenyltetrahydro-[1,3]dioxolo[4,5-e][1,3,2]dioxaphosphepine, is researched, Molecular C37H33O4P, CAS is 147700-62-7, about Ligand-Enabled Enantioselective Csp3 -H Activation of Tetrahydroquinolines and Saturated Aza-Heterocycles by RhI. Author is Gressies, Steffen; Klauck, Felix J. R.; Kim, Ju Hyun; Daniliuc, Constantin G.; Glorius, Frank.
The rhodium(I)-catalyzed enantioselective intermol. Csp3-H activation of various saturated aza-heterocycles including tetrahydroquinolines, piperidines, piperazines, azetidines, pyrrolidines, and azepanes is presented. The combination of a rhodium(I) precatalyst and a chiral monodentate phosphonite ligand is shown to be a powerful catalytic system to access a variety of important enantio-enriched heterocycles from simple starting materials. Notably, the Csp3-H activation of tetrahydroquinolines is especially challenging due to the adjacent Csp2-H bond. This redox-neutral methodol. provides a new synthetic route to α-N-arylated heterocycles with high chemoselectivity and enantioselectivity up to 97 % ee.
Compounds in my other articles are similar to this one((3aR,8aR)-2,2-Dimethyl-4,4,6,8,8-pentaphenyltetrahydro-[1,3]dioxolo[4,5-e][1,3,2]dioxaphosphepine)Application In Synthesis of (3aR,8aR)-2,2-Dimethyl-4,4,6,8,8-pentaphenyltetrahydro-[1,3]dioxolo[4,5-e][1,3,2]dioxaphosphepine, you can compare them to see their pros and cons in some ways,such as convenient, effective and so on.
Reference:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem