Waterson, Alex G.; Kennedy, J. Phillip; Patrone, James D.; Pelz, Nicholas F.; Feldkamp, Michael D.; Frank, Andreas O.; Vangamudi, Bhavatarini; Souza-Fagundes, Elaine M.; Rossanese, Olivia W.; Chazin, Walter J.; Fesik, Stephen W. published an article about the compound: 1,5-Diphenyl-1H-pyrazole-3-carboxylic acid( cas:13599-22-9,SMILESS:OC(=O)C1=NN(C(=C1)C1=CC=CC=C1)C1=CC=CC=C1 ).SDS of cas: 13599-22-9. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:13599-22-9) through the article.
Replication Protein A is the primary eukaryotic ssDNA binding protein that has a central role in initiating the cellular response to DNA damage. RPA recruits multiple proteins to sites of DNA damage via the N-terminal domain of the 70 kDa subunit (RPA70N). Here the authors describe the optimization of a diphenylpyrazole carboxylic acid series of inhibitors of these RPA-protein interactions. The authors evaluated substituents on the aromatic rings as well as the type and geometry of the linkers used to combine fragments, ultimately leading to submicromolar inhibitors of RPA70N protein-protein interactions.
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Reference:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem