Quality Control of Methyl 5-methoxyindole-2-carboxylate. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: Methyl 5-methoxyindole-2-carboxylate, is researched, Molecular C11H11NO3, CAS is 67929-86-6, about Synthesis and pharmacological evaluation of 1,2,3,4-tetrahydropyrazino[1,2-a]indole and 2-[(phenylmethylamino)methyl]-1H-indole analogues as novel melatoninergic ligands. Author is Markl, Christian; Attia, Mohamed I.; Julius, Justin; Sethi, Shalini; Witt-Enderby, Paula A.; Zlotos, Darius P..
Two novel series of melatonin-derived compounds have been synthesized and pharmacol. evaluated at the MT1 and MT2 subtypes of melatonin receptors. Compounds 12b-c are non-selective high-affinity MT1 and MT2 receptor ligands (K i = 7-11 nM). Compound 12b had little intrinsic activity at the MT1 receptor and no intrinsic activity at the MT2 receptor. Compound 20d displayed the highest MT2 binding affinity (K i = 2 nM) and moderate selectivity toward the MT2 subtype (K i MT1/MT2 ratio = 8) behaving as MT2 antagonist and MT1 agonist (IC50 = 112 pM). The findings help define SARs around the positions 1 and 2 of melatonin with respect to binding affinity, MT2 selectivity, and intrinsic activity.
This compound(Methyl 5-methoxyindole-2-carboxylate)Quality Control of Methyl 5-methoxyindole-2-carboxylate was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.
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Isoquinoline – Wikipedia,
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