Formula: C17H14NP. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: Diphenyl-2-pyridylphosphine, is researched, Molecular C17H14NP, CAS is 37943-90-1, about Site-specific DNA functionalization through the tetrazene-forming reaction in ionic liquids. Author is Ishizawa, Seiya; Tumurkhuu, Munkhtuya; Gross, Elizabeth J.; Ohata, Jun.
Development of multiple chem. tools for deoxynucleic acid (DNA) labeling has facilitated wide use of their functionalized conjugates, but significant practical and methodol. challenges remain to achievement of site-specific chem. modification of the biomacromol. As covalent labeling processes are more challenging in aqueous solution, use of nonaqueous, biomol.-compatible solvents such as an ionic liquid consisting of a salt with organic mol. architecture, could be remarkably helpful in this connection. Herein, we demonstrate site-specific chem. modification of DNAs through a tetrazene-forming amine-azide coupling reaction using an ionic liquid This ionic liquid-enhanced reaction process has good functional group tolerance and precise chemoselectivity, and enables incorporation into DNA of various useful functionalities such as biotin, cholesterol and fluorophores which could be incorporated into DNA through this method. A site-specifically labeled single stranded nucleotide, or aptamer interacting with a growth factor receptor (Her2) was successfully used in the fluorescence imaging of breast cancer cell lines. The non-traditional medium-promoted labeling strategy described here provides an alternative design paradigm for future development of chem. tools for applications involving DNA functionalization.
This compound(Diphenyl-2-pyridylphosphine)Formula: C17H14NP was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.
Reference:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem