Isoquinoline’s properties: Isoquinoline is a colorless hygroscopic liquid at temperatures above its melting point with a penetrating, 1532-97-4, formula is C9H6BrN, Name is 4-Bromoisoquinoline. unpleasant odor. Impure samples can appear brownish, as is typical for nitrogen heterocycles. Category: isoquinoline.
Momiyama, Norie;Izumiseki, Atsuto;Ohtsuka, Naoya;Suzuki, Toshiyasu research published 《 Correlations between Substituent Effects and Catalytic Activities: A Quantitative Approach for the Development of Halogen-Bonding-Driven Anion-Binding Catalysts》, the research content is summarized as follows. A quant. approach for the development of halogen-bonding-driven anion-binding catalysts was studied using 4-substituted perfluorinated iodobenzene. 19F NMR titrations were used to determine the binding constants K for chloride, and their catalytic activities were evaluated in the allylation reaction of a N-activated pyridine. We discovered that the log K and product yields were linearly correlated, and that they were dependent on the Hammett substituent parameter, σmeta (r2=0.99). This linear correlation provided a quant. predictive model for both the binding constant and the reaction yield. Concomitantly, this efficiently permitted the development of a highly active anion-binding catalyst, namely 4-CNC6F4I (K=489±5 M-1). Addnl., the catalytic activity of 4-CNC6F4I was established in the allylation and crotylation of N-activated isoquinolines (7 examples). Overall, this approach highlights the value of quant. anal. by exploring exptl. informed correlations in the development of halogen bond donor catalysts.
Category: isoquinoline, 4-Bromoisoquinoline, also known as 4-Bromoisoquinoline, is a useful research compound. Its molecular formula is C9H6BrN and its molecular weight is 208.05 g/mol. The purity is usually 95%.
4-Bromoisoquinoline is an aryl halide that can be used in the cross-coupling reaction with other aryl halides. It has been shown to have anticancer activity and to inhibit the growth of tumour cell lines in vitro. This compound is also efficient for inhibiting leukemia cells. 4-Bromoisoquinoline has been shown to have an inhibitory effect on cancer cells through the inhibition of DNA synthesis and RNA transcription, as well as by inducing apoptosis. The mechanism of action may be due to its ability to bind to aromatic hydrocarbons and halides, which leads to thermodynamic changes and vibrational energy transfer., 1532-97-4.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem