Pan, Guihua; He, Changli; Chen, Min; Xiong, Qian; Cao, Weidi; Feng, Xiaoming published the artcile< Synthesis of dihydroisoquinoline and dihydropyridine derivatives via asymmetric dearomative three-component reaction>, Quality Control of 90806-58-9, the main research area is dihydroisoquinoline dihydropyridine diastereoselective enantioselective; heteroarene allenoate methyleneindolinone asym dearomative three component reaction.
Authors report the first asym. three-component nucleophilic addition/dearomative [4+2] cycloaddition/isomerization cascade of transient dipoles generated from N-heteroarenes and allenoates with methyleneindolinones in the presence of chiral N,N’-dioxide/metal complexes. This tandem reaction enabled rapid access to versatile chiral polycyclic N-heterocycles with good to excellent enantioselectivities under mild reaction conditions in spite of the strong background reaction, including 1,2-dihydroisoquinoline, 1,2-dihydropyridine derivatives, and others. Meanwhile, a series of control experiments were conducted to elucidate the reaction mechanism and the roles of additives.
CCS Chemistry published new progress about [4+2] Cycloaddition reaction. 90806-58-9 belongs to class isoquinoline, and the molecular formula is C10H9NO, Quality Control of 90806-58-9.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem