Zhang, Dong; Cai, Jinlin; Du, Jinze; Wang, Qingdong; Yang, Jinming; Geng, Rongqing; Fang, Zheng; Guo, Kai published the artcile< Electrochemical-Oxidation-Promoted Direct N-ortho-Selective Difluoromethylation of Heterocyclic N-Oxides>, Computed Properties of 90806-58-9, the main research area is difluoromethyl quinoline isoquinoline oxide preparation green chem; isoquinoline quinoline oxide electrochem oxidation ortho selective difluoromethylation.
An efficient and green electrochem. N-ortho-selective difluoromethylation method of various quinoline and isoquinoline N-oxides has been developed. In this method sodium difluoromethanesulfinate (HCF2SO2Na) was used as the source of difluoromethyl moiety and various N-ortho-selective difluoromethylation quinolines and isoquinolines N-oxides were obtained in good to excellent yield under constant current. In addition, the reaction was easy to scale up and maintains good yields. Preliminary mechanism studies suggested that the reaction has underwent a free radical addition and hydrogen elimination pathway.
Organic Letters published new progress about Difluoromethylation. 90806-58-9 belongs to class isoquinoline, and the molecular formula is C10H9NO, Computed Properties of 90806-58-9.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem