On July 29, 2004, Taveras, Arthur G.; Aki, Cynthia J.; Bond, Richard W.; Chao, Jianping; Dwyer, Michael; Ferreira, Johan A.; Chao, Jianhua; Yu, Younong; Baldwin, John J.; Kaiser, Bernd; Li, Ge; Merritt, J. Robert; Biju, Purakkattle J.; Nelson, Kingsley H.; Rokosz, Laura L.; Jakway, James P.; Lai, Gaifa; Wu, Minglang; Hecker, Evan A.; Lundell, Daniel; Fine, Jay S. published a patent.Application of 74904-29-3 The title of the patent was Preparation of 3,4-diaminocyclobutene-1,2-diones as CXC-chemokine receptor ligands. And the patent contained the following:
Title compounds [I; A = (substituted) pyridylmethyl, thiazolylmethyl, benzofurylmethyl, isoxazolylmethyl, pyrazinylmethyl, triazolylmethyl, phenylalkyl, etc.; B = (substituted) Ph, benzotriazolyl, benzimidazolyl, imidazolyl, pyrazolyl, hydroxypyridinyl, thienyl, pyrrolyl, isothiazolyl, etc.], were prepared Thus, title compound (II) (preparation outlined) showed Ki = 0.8 nM in a CXCR2 SPA receptor binding assay. The experimental process involved the reaction of 8-Methoxy-3,4-dihydroisoquinolin-1(2H)-one(cas: 74904-29-3).Application of 74904-29-3
The Article related to aminocyclobutenedione preparation cxc chemokine receptor ligand, cyclobutenedione diamino preparation cxc chemokine receptor ligand, squaric acid amide preparation cancer pain inflammation contusion treatment and other aspects.Application of 74904-29-3
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem