On April 22, 2004, Taveras, Arthur G.; Chao, Jianhua; Biju, Purakkattle J.; Yu, Younong; Fine, Jay S.; Hipkin, William; Aki, Cynthia J.; Merritt, J. Robert; Li, Ge; Baldwin, John J.; Lai, Gaifa; Wu, Minglang; Hecker, Evan A. published a patent.Computed Properties of 74904-29-3 The title of the patent was Preparation of diaminothiadiazole dioxides and monoxides as CXC- and CC-chemokine receptor ligands. And the patent contained the following:
Disclosed are diaminothiadiazole mono- and dioxides (shown as I; e.g. II) and the pharmaceutically acceptable salts and solvates thereof. Examples of substituent A include heteroaryl, aryl, heterocycloalkyl, cycloalkyl, aryl, alkynyl, alkenyl, aminoalkyl, alkyl or amino; examples of substituent B include aryl and heteroaryl; g = 1, 2. Also disclosed is a method of treating a chemokine mediated diseases, such as, cancer, angiogenesis, angiogenic ocular diseases, pulmonary diseases, multiple sclerosis, rheumatoid arthritis, osteoarthritis, stroke and cardiac reperfusion injury, acute pain, acute and chronic inflammatory pain, and neuropathic pain using I. Although the methods of preparation are not claimed, hundreds of example preparations and/or characterization data are included. For example, II was prepared in 31% yield from the 4-methoxy analog and isopropylamine in the presence of DIEA in MeOH; the 4-methoxy analog was prepared from the dimethoxy analog and N,N-dimethyl-3-amino-2-hydroxybenzamide in 99% crude yield. Antagonist activities of some examples of I towards CXCR1, CXCR2 and CCR7 are given. The experimental process involved the reaction of 8-Methoxy-3,4-dihydroisoquinolin-1(2H)-one(cas: 74904-29-3).Computed Properties of 74904-29-3
The Article related to aminothiadiazole oxide dioxide preparation chemokine receptor antagonist, thiadiazole diamino oxide dioxide preparation chemokine receptor antagonist, Heterocyclic Compounds (More Than One Hetero Atom): Other 5-Membered Rings, Two Or More Hetero Atoms and other aspects.Computed Properties of 74904-29-3
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem