Kavetsou, Eleni published the artcileNovel 3-aryl-5-substituted-coumarin analogues: Synthesis and bioactivity profile, COA of Formula: C9H10O3, the main research area is phenyl methylcoumarin preparation antioxidant antitumor lipoxygenase inhibition SAR docking; acetyloxy-moiety; coumarins; cytotoxicity; lipoxygenase; molecular modeling; oxyprenylated analogues.
Eighteen 3-phenyl-5-substituted-coumarins, among them six were 5-acetyloxy-derivatives, six 5-hydroxy-derivatives and six 5-geranyloxy-derivatives I [R = hydroxy, acetoxy, geranyloxy; R1 = H, MeO, Br; R2 = H, MeO, Br, O2N, etc.] were synthesized, structurally characterized and their antioxidant activity, lipoxygenase inhibitory ability, as well as their cytotoxic activity against human neuroblastoma SK-N-SH and HeLa adenocarcinoma cell lines were evaluated. The compounds I [R = hydroxy, acetoxy, geranyloxy; R1 = H, MeO, Br; R2 = H, MeO, Br, O2N, etc.] were found to be the best cytotoxic agents among all the compounds studied. The bromo-substituted coumarins I [R = acetoxy, R1 = H, R2 = Br; R = acetoxy, R1 = Br, R2 = H] were remarkably active against HeLa cell line showing IC50 1.8 and 6.1μM, resp. Coumarin I [R = geranyloxy, R1 = MeO, R2 = H] presented dual bioactivity, while compound I [R = geranyloxy, R1 = H, R2 = MeO] was the most competent soybean lipoxygenase inhibitor of this series (IC50 10μM). As shown by in-silico docking studies, the studied mols. present allosteric interactions with soybean lipoxygenases.
Drug Development Research published new progress about Antioxidants. 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, COA of Formula: C9H10O3.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem