Li, Zhen published the artcileThermodynamic and kinetic studies of hydride transfer from Hantzsch ester under the promotion of organic bases, Related Products of isoquinoline, the main research area is hydride transfer kinetics thermodn Hantzsch ester promotion organic base.
Base-promoted hydride transfer (BPHyT), a strategy for the upconversion of hydride donors, was studied here in a three-component system, composed of Hantzsch ester (HEH), acridinium derivatives and organic bases. Based on the thermodn. parameters of hydricity and pKa, we proposed a thermodn. cycle to evaluate the apparent hydricity of HEH/base combinations, as well as the overall driving force of BPHyT. Bronsted-type linear anal. indicated that the base used in BPHyT is much more effective to regulate the reaction kinetics, compared to conventional Bronsted acid or base catalysis. Structure-reactivity relationships showed that the hydride acceptor and the base contribute equally to regulate the kinetics of BPHyT. Kinetic isotope effects suggested that the hydride transfer is involved in the rate-determining step. Reductions of the polar C:C bonds by HEH/base combinations were performed to confirm the feasibility of applying BPHyT in organic synthesis.
Organic Chemistry Frontiers published new progress about Base catalysis. 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, Related Products of isoquinoline.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem