Liao, Yangzhen published the artcileTransition-metal-free radical relay cyclization of vinyl azides with 1,4-dihydropyridines involving a 1,5-hydrogen-atom transfer: access to α-tetralone scaffolds, HPLC of Formula: 1205-17-0, the main research area is tetralone scaffold preparation green chem diastereoselective; vinyl azide dihydropyridine radical hydrogen transfer cyclization.
The remote C(sp3)-H functionalization enabled by a radical-mediated 1,5-hydrogen-atom transfer (HAT) process using 1,4-dihydropyridines I (R = cyclohexyl, 3-phenyl-2-methylpropyl, 1-cyclohexylethyl, etc.; R1 = C(O)OEt, CN) and vinyl azides R2C(=CH2)N3 (R2 = 2-chlorophenyl, 1-naphthyl, benzofuran-2-yl, etc.) as precursors has been described. In this study, 1,4-dihydropyridines I can function as 1,2-diradical synthons through sequential homolytic cleavage of an ipso-C-C bond and a β-C(sp3)-H bond. This reaction offers facile access to a diverse range of α-tetralones e.g., II with excellent stereoselectivity. The utility of the present method is further highlighted by its application to rapid assembly of the tetracyclic scaffold present in furanosteroids as well as the synthesis of aromatic amines.
Organic Chemistry Frontiers published new progress about C-C bond formation. 1205-17-0 belongs to class isoquinoline, name is 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, and the molecular formula is C11H12O3, HPLC of Formula: 1205-17-0.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem