Peng, Mengqi published the artcilePentafluorophenyl Group as Activating Group: Synthesis of α-Deuterio Carboxylic Acid Derivatives via Et3N Catalyzed H/D Exchange, Recommanded Product: 4-Methoxyphenylacetic acid, the main research area is pentafluorophenylacetate deuterium oxide triethylamine catalyst regioselective deuteration tandem; pentafluorophenyl dideuterioacetate preparation.
Discovered that highly regioselective H/D exchange was achieved on the α-position of the pentafluorophenyl (Pfp) ester using Et3N as the catalyst and D2O as the deuterium source. Computational and exptl. results showed that the Pfp group can significantly increase the acidity of the α-hydrogen of the ester. This mild reaction condition tolerated a variety of functional groups. 90%â?8% yields and 91%â?8% deuterium incorporations were obtained with all the tested Pfp esters. Taking advantage of the high reactivity of Pfp esters, a series of valuable α-deuterio carboxylic acid derivatives, including herbicide, drugs and drug intermediates, was synthesized using α-deuterio Pfp esters as precursors.
Advanced Synthesis & Catalysis published new progress about Carboxylic esters Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Recommanded Product: 4-Methoxyphenylacetic acid.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem