Cui, Xin-Feng published the artcileRhodium-catalyzed tandem acylmethylation/annulation of N-nitrosoanilines with sulfoxonium ylides for the synthesis of substituted indazole N-oxides, Quality Control of 5961-59-1, the main research area is indazole nitrogen oxide preparation; nitrosoaniline sulfoxonium ylide acylmethylation cyclization rhodium catalyst.
An atom-economical protocol for synthesizing indazole N-oxides e.g., I from readily available N-nitrosoanilines e.g., C6H5N(CH3)N(=O) and sulfoxonium ylides RC(O)CH=S(O)(CH3)2 (R = Ph, cyclohexyl, furan-2-yl, t-Bu, etc.) through the rhodium(III)-catalyzed C-H activation and cyclization reaction is described here. This protocol employs nitroso as a traceless directing group. The transformation features powerful reactivity, tolerates various functional groups, and proceeds with moderate to good yields under an ambient atm., providing a straightforward approach to access structurally diverse and valuable indazole N-oxide derivatives e.g., I. Importantly, this new annulation process represents a hitherto unobserved reactivity pattern for the N-nitroso group.
Organic & Biomolecular Chemistry published new progress about C-H bond activation. 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Quality Control of 5961-59-1.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem