Khan, Jabir published the artcileSilyl Cation-Initiated, Bronsted Acid-Catalyzed Strategy toward Unsymmetrical 3,3-Disubstituted 2-Oxindoles and Azonazine Cores, Recommanded Product: 1,3-Dimethoxybenzene, the main research area is diaryl oxindole regioselective preparation; keto amide arene Friedel Craft cyclization Bronsted acid catalyst; sulfenylated oxindole derivative regioselective preparation; thiophenol keto amide Friedel Craft cyclization Bronsted acid catalyst; tetracyclic azonazine preparation; oxindole diaryl Friedel Craft cyclization Bronsted acid catalyst.
Herein, a mild, metal-free, robust approach for synthesizing valuable and sterically demanding unsym. 3,3-diaryl 2-oxindoles I [R = Me, Ph; R1 = Ph, 4-MeOC6H4, 4-OH-3-MeC6H4, etc.; R2 = H, Me, Ph, Bn; R3 = H, 5-OMe, 5-Br, etc.] and 3-sulfenylated 2-oxindole derivatives II [R4 = Me, Ph; R5 = nBu, Ph, Bn, etc.; R6 = H, Me, Ph, Bn] via reductive cyclization of α-ketoamides with arenes /thiophenols was reported. This operationally simple protocol was initiated by a silyl cation and further catalyzed by a Bronsted acid. The products were afforded in excellent regioselectivity and good functional group tolerance. Also, ring-closing reaction of compounds I under similar reaction conditions afforded scaffolds of azonazine and its derivatives III [R7 = H, 2-Cl-6-Me; R8 = H, Me, Ph, Bn; R9 = Me, Cl, F; R10 = Me, Ph] with an excellent syn-diastereoselectivity bearing all-carbon quaternary stereocenters.
Journal of Organic Chemistry published new progress about Amines Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, Recommanded Product: 1,3-Dimethoxybenzene.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem