Leischner, Thomas published the artcileHighly selective hydrogenation of amides catalysed by a molybdenum pincer complex: scope and mechanism, Safety of 4-Methoxy-N-methylaniline, the main research area is methyl formanilide molybdenum pincer complex catalyst chemoselective hydrogenation; methylaniline preparation.
A series of molybdenum pincer complexes showed for the first time to be active in the catalytic hydrogenation of amides. Among the tested catalysts, I proved to be particularly well suited for the selective C-N hydrogenolysis of N-methylated formanilides. Notably, high chemoselectivity was observed in the presence of certain reducible groups including even other amides. The general catalytic performance as well as selectivity issues was rationalized taking an anionic Mo(0) as the active species. The interplay between the amide CO reduction and the catalyst poisoning by primary amides accounted for the selective hydrogenation of N-methylated formanilides. The catalyst resting state was found to be a Mo-alkoxo complex formed by reaction with the alc. product. This species played two opposed roles – it facilitated the protolytic cleavage of the C-N bond but it encumbered the activation of hydrogen.
Chemical Science published new progress about Anilines Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Safety of 4-Methoxy-N-methylaniline.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem