Li, Wen-Duo published the artcileIron-Catalyzed Selective N-Methylation and N-Formylation of Amines with CO2, Computed Properties of 5961-59-1, the main research area is methylamine selective preparation; amine carbon dioxide methylation iron catalyst triphenylphosphine; formamide selective preparation; carbon dioxide amine formylation iron catalyst tributylphosphine.
An efficient protocol for the synthesis of methylamines R1N(CH3)R2 [R1 = Ph, 4-MeOC6H4, 2-pyridyl, etc.; R2 = H, Me, cyclohexyl, etc.] and formamides R1N(CHO)R2 was developed via iron-catalyzed selective N-methylation and N-formylation of amines with CO2 as sustainable C1 source under mild reaction conditions. Herein iron-catalyzed methylation and formylation of amines was achieved with ligands triphenylphosphine and tributylphosphine resp. The method was successfully applied in the late-stage methylation and formylation of drug mols. containing amine moiety. This catalytic system featured high efficiency and good substrate scope using com. available iron catalyst and mono-phosphine ligands.
Advanced Synthesis & Catalysis published new progress about Formamides Role: SPN (Synthetic Preparation), PREP (Preparation). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Computed Properties of 5961-59-1.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem