McLaughlin, Calum published the artcileBase-free Enantioselective C(1)-Ammonium Enolate Catalysis Exploiting Aryloxides: A Synthetic and Mechanistic Study, COA of Formula: C9H10O3, the main research area is base free enantioselective ammonium enolate isothiourea catalysis aryloxide; Michael addition aryl ester vinyl bissulfone; VTNA; enantioselective Michael addition; inverse secondary kinetic isotope effect; isothiourea catalysis; mechanistic analysis.
An isothiourea-catalyzed enantioselective Michael addition of aryl ester pronucleophiles to vinyl bis-sulfones via C(1)-ammonium enolate intermediates has been developed. This operationally simple method allows the base-free functionalization of aryl esters to form α-functionalized products containing two contiguous tertiary stereogenic centers in excellent yield and stereoselectivity (all ≥99:1 er). Key to the success of this methodol. is the multifunctional role of the aryloxide, which operates as a leaving group, Bronsted base, Bronsted acid and Lewis base within the catalytic cycle. Comprehensive mechanistic studies, including variable time normalization anal. (VTNA) and isotopologue competition experiments, have been carried out. These studies have identified (i) orders of all reactants; (ii) a turnover-limiting Michael addition step, (iii) product inhibition, (iv) the catalyst resting state and (v) catalyst deactivation through protonation.
Angewandte Chemie, International Edition published new progress about Diastereoselective synthesis. 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, COA of Formula: C9H10O3.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem