Zhang, Qifeng published the artcileSulfur(IV)-mediated umpolung α-heterofunctionalization of 2-oxazolines, Application of 4-Methoxy-N-methylaniline, the main research area is alkyloxazoline nucleophile phenoxathiin sulfoxide umpolung functionalization; oxazoline preparation phenoxathiin sulfoxide oxidant.
The α-umpolung of carbonyl compounds significantly expands the boundaries of traditional carbonyl chem. Despite various umpolung methods available today, reversing the inherent reactivity ofcarbonyls still remains a substantial challenge. In this article, the authors report the first use of sulfonium salts, in lieu of well-established hypervalent iodines, for the carbonyl umpolung event. The protocol enables the incorporation of a wide variety of heteroatom nucleophiles into the α-carbon of 2-oxazolines. The success of this investigation hinges on the following factors: (1) the use of sulfoxides, which are abundant, structurally diverse and tunable, and easily accessible, ensures the identification of a superior oxidant namely phenoxathiin sulfoxide for the umpolung reaction; (2) the “”assembly/deprotonation”” protocol previously developed for rearrangement reactions in the authors’ laboratory was successfully applied here for the construction of α-umpoled 2-oxazolines.
Chemical Science published new progress about Free energy, free energy surface. 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Application of 4-Methoxy-N-methylaniline.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem