Zheng, Jie published the artcileCascade intramolecular Prins/Friedel-Crafts cyclization for the synthesis of 4-aryltetralin-2-ols and 5-aryltetrahydro-5H-benzo[7]annulen-7-ols, COA of Formula: C8H10O2, the main research area is aryl tetralinol diastereoselective preparation; acetaldehyde nucleophile Prins Friedel Craft boron trifluoride etherate catalyst; tetrahydrobenzoannulinol aryl diastereoselective preparation; propanal nucleophile Prins Friedel Craft boron trifluoride etherate catalyst; 4-aryltetralin-2-ol; 5-aryl-benzo[7]annulen-7-ol; Prins/Friedel–Crafts; cascade reaction.
The treatment of 2-(2-vinylphenyl)acetaldehydes or 3-(2-vinylphenyl)propanal with BF3·Et2O catalyzed intramol. Prins reaction afforded intermediary benzyl carbenium ions, which were then trapped by a variety of electron-rich aromatics via Friedel-Crafts alkylation. This cascade Prins/Friedel-Crafts cyclization protocol paved an expedient path to medicinally useful 4-aryltetralin-2-ol I [R1 = H, OMe, Cl, NO2; R2 = H, Me; R3 = H, Me, Ph; R4 = 2-furyl, 2-thienyl, 3,4-(MeO)2C6H3, etc.] and 5-aryltetrahydro-5H-benzo[7]annulen-7-ol derivatives II [R5 = 2-furyl, 3,4-(MeO)2C6H3].
Beilstein Journal of Organic Chemistry published new progress about Aromatic alcohols Role: PRP (Properties), RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, COA of Formula: C8H10O2.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem