Xia, Yujia published the artcileNH4I-promoted oxidative formation of benzothiazoles and thiazoles from arylacetic acids and phenylalanines with elemental sulfur, Name: 4-Methoxyphenylacetic acid, the main research area is arylbenzothiazole preparation; arylacetic acid amine sulfur oxidative cyclization catalyst ammonium iodide; benzyl arylthiazole preparation; aryl alanine sulfur oxidative cyclization catalyst ammonium iodide.
A NH4I/K3PO4-based catalytic system had been established to enable oxidative formation of thiazole compounds I [R1 = H, MeO; R2 = H, MeO, t-Bu; R3 = H, MeO; R1R2 = HC=CHCH=CH, HC=CHCH=N, HC=CHC(Br)=CH, HC=CHC(4-methoxyphenyl)=CH; R2R3 = OCH2O; Ar = Ph, 3-pyridyl, 2-naphthyl, etc.], II [Ar = Ph, 4-MeC6H4, 2,4-di-ClC6H3, etc.] from arylacetic acids and phenylalanines with elemental sulfur. While the three-component reaction of anilines or β-naphthylamines with arylacetic acids and elemental sulfur afforded benzo[2,1-d]thiazoles I [R1 = H, MeO; R2 = H, MeO, t-Bu; R3 = H, MeO; R2R3 = OCH2O; Ar = Ph] and naphtho[2,1-d]thiazoles, I [R1R2 = HC=CHCH=CH, HC=CHCH=N, HC=CHC(Br)=CH, HC=CHC(4-methoxyphenyl)=CH; Ar = Ph, 3-pyridyl, 2-naphthyl, etc.] the annulation of phenylalanines with elemental sulfur produces 2-benzyl II [Ar = Ph] and 2-benzoylthiazoles. This work well complements previous three-component annulations of benzothiazoles from other coupling partners.
Organic & Biomolecular Chemistry published new progress about Amino acids, analogs Role: RCT (Reactant), RACT (Reactant or Reagent) (phenylalanine). 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Name: 4-Methoxyphenylacetic acid.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem