Gomez-Angel, Andres R. published the artcileSynthesis and functionalization of a bifunctional normorphan 3D building block for medicinal chemistry, COA of Formula: C8H10O2, the main research area is bifunctional normorphan 3D building block diastereoselective preparation.
A multi-gram-scale synthetic route to a novel, bifunctional normorphan 3D building block bearing orthogonally reactive vinyl MIDA boronate and N-2,4-dimethoxybenzyl (DMB) amide functional handles I was developed. Synthetic manipulation at each of the functional handles was demonstrated including Suzuki-Miyaura cross-coupling, exo-diastereoselective hydrogenation, N-DMB group removal and lactam reduction Normorphan cores derived from the building block satisfied AstraZeneca’s ‘rule of 2’ for building blocks and had a high fraction of sp3 hybridized carbon atoms (Fsp3). A virtual lead-like library of 344 compounds derived from the building block had attractive lead-like properties. The 3D building block was commercialised by Redbrick Mol. and was available for purchase.
Tetrahedron published new progress about Aryl bromides Role: RCT (Reactant), RACT (Reactant or Reagent). 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, COA of Formula: C8H10O2.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem