Yuan, Yu-Chao published the artcileEnantiopure isothiourea@carbon-based support: stacking interactions for recycling a lewis base in asymmetric catalysis, HPLC of Formula: 104-01-8, the main research area is chiral isothiourea functionalized pyrene preparation; oxazolidinone oxaziridine arylacetic anhydride isothiourea Lewis base asym catalysis.
The synthesis of a chiral isothiourea (hyperBTM) I functionalized by a pyrene moiety was described via click chem. This new enantiopure Lewis base was used as supported catalyst thanks to its immobilization on reduced graphene oxide via strong π-π interactions between the polyaromatic core and the carbon support. The synthesis of scalemic oxazolidin-4-ones II [Ar = Ph, 2-naphthyl, 4-FPh, 4-MeOPh] from oxaziridines and arylacetic anhydrides was chosen as a test reaction to assess the validity of the process, this transformation having never been carried out under recycling conditions. Optimization of the reaction conditions led to the synthesis of the targeted products in high yields and good to excellent enantioselectivity values with the supported catalyst. Recovery of the active species occurred by simple filtration, the immobilized catalyst was then successfully reengaged in seven consecutive cycles while maintaining its efficiency. The robustness of this chiral organic isothiourea was also demonstrated in an original multi-substrate procedure.
Organic Chemistry Frontiers published new progress about [3+2] Cycloaddition reaction, stereoselective. 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, HPLC of Formula: 104-01-8.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem