Feng, Xinshu published the artcileEffect of the ancillary ligand in N-heterocyclic carbene iridium(III) catalyzed N-alkylation of amines with alcohols, Application In Synthesis of 5961-59-1, the main research area is alkylation benzyl alc aromatic amine preparation secondary benzylarylamine; amine alkylation hydrogen transfer borrowing mechanism iridium catalyst; iridium NHC half sandwich catalyst alkylation aromatic amine alc; crystal structure iridium NHC half sandwich complex alkylation catalyst; mol structure iridium NHC half sandwich complex alkylation catalyst.
A series of air-stable N-heterocyclic carbene (NHC) Ir(III) complexes (Ir1-Ir6), bearing various combinations of chlorine, pyridine and NHC ligands, were assayed for the N-alkylation of amines with alcs. It was found that Ir3, with two monodentate 1,3-bis-methyl-imidazolylidene (IMe) ligands, emerged as the most active complex. A large variety of amines and primary alcs. were efficiently converted into mono-N-alkylated amines in 53-96% yields. As a special highlight, for the challenging MeOH, selective N-monomethylation could be achieved using KOH as a base under an air atm. Moreover, this catalytic system was successfully applied to the gram-scale synthesis of some valuable compounds
Polyhedron published new progress about Alkylation (dehydrative N-alkylation). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Application In Synthesis of 5961-59-1.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem