Thanh, Nguyen Dinh published the artcileEfficient click chemistry towards novel 1H-1,2,3-triazole-tethered 4H-chromene-D-glucose conjugates: Design, synthesis and evaluation of in vitro antibacterial, MRSA and antifungal activities, Related Products of isoquinoline, the main research area is benzaldehyde chromene glucose click antibacterial aminoglycoside preparation human; chromene glucose click antibacterial antifungal MRSA crystal structure aminoglycoside; antifungal MRSA click alkyne azide triazole cycloaddition catalyst preparation; 1H-1,2,3-Triazoles; 2-Amino-4H-chromene-3-carbonitriles; Antibacterial; Antifungal; Click chemistry; Cu@MOF-5; Cytotoxicity; Propargyl ether; Sugar azide.
The series of 2-amino-7-propargyloxy-4H-chromene-3-carbonitriles were synthesized from corresponding 2-amino-7-phydroxy-4H-chromene-3-carbonitriles and propargyl bromide. Two procedures were used in these syntheses: K2CO3/acetone and NaH/DMF procedures with yields of 65-89% and 80-96%, resp. 1H-1,2,3-triazole-tethered 4H-chromene-D-glucose conjugates were synthesized using click chem. of propargyl ethers and tetra-O-acetyl-β-D-glucopyranosyl azide. CuMOF-5 was the optimal catalyst for this chem. The yields of 1H-1,2,3-triazoles were 80-97.8%. All triazole glycosides were evaluated in vitro for anti-microorganism activities. Among tested compounds with MIC values of 1.56-6.25 μM, there were four compounds against B. subtilis, four compounds against S. aureus, and four compounds against S. epidermidis; five compounds against E. coli, four compounds against K. pneumoniae, five compounds against P. aeruginosa, and six compounds against S. typhimurium. Some title compounds had MIC values of 1.56-6.25 μM for three clin. methicillin resistant Staphylococcus aureus (MRSA) isolates. Some compounds had inhibitory activities against four fungi, including A. niger, A. flavus, C. albicans, and S. cerevisiae, with MIC values of 1.56-6.25 μM. Some 1H-1,2,3-triazoles had comparatively low toxicity against RAW 264.7 cells.
European Journal of Medicinal Chemistry published new progress about 1,3-Dipolar cycloaddition reaction. 86-51-1 belongs to class isoquinoline, name is 2,3-Dimethoxybenzaldehyde, and the molecular formula is C9H10O3, Related Products of isoquinoline.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem